Abstract
Eight-week-old mice of 3 sublines of strain C57BL 6 were given s.c. injections of 1,2-dimethylhydrazine (DMH), once weekly for 10 weeks. The highest incidence (85%) of colorectal tumors occurred in C57BL 6N mice. Colorectal tumors occurred in 43% of C57BL 6 J mice, while only 3 (10%) C57BL 6 Ha mice developed these tumors. Possible factors responsible for the differential susceptibility of 3 sublines of C57BL 6 mice to the induction of colorectal tumors by DMH are discussed.
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