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Abstract
We examined the inbred mouse strains DBA/2Ibg, C57BL/6Ibg and C3H/2Ibg for differences in susceptibility to bicuculline-induced seizures, as well as to bicuculline-induced epileptiform activity recorded in the CA1 pyramidal cell layer of hippoeampal slices. For susceptibility to seizure onset the strain rank order was (most to least susceptible):C3H=DBA>C57. The rank order for sensitivity to effects of bicuculline on tonic seizure latency and on hippoeampal epileptiform activity were identical: C3H=DBA>C57. It is suggested that mechanisms underlying the development of bicuculline-induced epileptiform events in the hippoeampal slice may be similar to those involved in the development of tonic seizures measured in vivo.
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