Abstract
The presynaptic neurotoxin omega-conotoxin (ω-CgTx) was tested for its ability to inhibit voltage-dependent calcium flux and transmitter release in rat brain synaptosomes. Conotoxin (0.001–10 μM) had no effect on calcium uptake or endogenous dopamine release from rat striatal synaptosomes in the absence of potassium depolarization. Fast-phase potassium stimulated calcium influx was only partially (20–30%) inhibited by conotoxin at concentrations between 1 nM and 10 μM. The fast-phase release of endogenous dopamine from the same synaptosomal preparation was inhibited by approximately 25% at 0.01 μM and by 60% at 10 μM. These results suggest that a subgroup of high affinity ω-CgTx-sensitive calcium channels may be involved in regulating the release of endogenous dopamine from brain synaptosomes.
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