Abstract
The effects of mercury compounds in rat glioma (C-6) and mouse neuroblastoma (NBP 2) cells in culture were studied. Glioma cells were more sensitive to methylmercuric chloride (CH 3HgCl) than neuroblastoma (NB) cells for the criterion of growth inhibition (due to cell death and inhibition of cell division). This may be due in part to the fact that glioma cells accumulated more CH 3 203HgCl than NB cells. The biological half-life of CH 3 203HgCl in glioma cells was less (3.2–5.2 hr) than that in NB cells (7 – 7.3 hr). Although a much higher concentration of mercuric chloride (HgCl 2) was required to produce effects similar to those produced by CH 3HgCl, it produced no differential effects on glioma and NB cells.
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