Abstract
Robust determination of the parameters governing the stability of the amorphous drugs is one of the key tasks of modern pharmaceutics. The kinetic stability of such systems is of crucial importance, as it affects their practical applications. In the present work we have determined the critical cooling rates, and the kinetic parameters of the cold crystallization of four slowly crystallizing sulfonamides, i.e. sulfaguanidine, sulfapyridine, sulfalene, and sulfadimidine. The Nakamura crystallization model was shown to have a good prognostic ability, as it allows determination of the stability time profile of the drug systems prone to crystallization from the non-isothermal thermokinetic data.
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