Abstract
Soy isoflavones enhanced radiation-induced cell killing of prostate cancer (PCa) cells in vitro and inhibited prostate tumor growth in vivo in pre-clinical models. Soy acts as an anti-oxidant in normal tissues. PCa patients treated with soy and radiotherapy (RT) had improved urinary, gastrointestinal and sexual functions, suggesting that soy could decrease RT toxicity in normal tissues. RT treatment of locally-advanced lung cancer (NSCLC) is limited by radiation-induced pneumonitis and fibrosis.
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