Abstract
Abstract CD4 and CD8 T cells produce different cytokines during immune response. Using a model of respiratory syncytial virus (RSV) infection, isolated CD4 T cells were found to produce predominantly Th2, while CD8 produced predominantly Th1 cytokines. To better understand the contribution of CD4 and CD8 T cells in immune pathology during RSV infection, CD4 and CD8 T cells were depleted using specific depleting antibodies and immune response was compared with control mice during RSV infection. Depletion of CD8 T cells showed increased airway hyperresponsiveness (AHR), production of IL-13, as well as increased mucus-associated gene, Gob5, expression. Specific depletion of CD4 induced lower AHR compared to control mice, lower Th2 cytokines and reduced Gob5 production. PAS staining showed both control and CD8 depleted mice with increase mucus production and increased goblet cell hyperplasia whereas mice depleted of CD4 T cell did not produce mucus. These results indicate that CD8 T cells are protective whereas CD4 T cells are responsible for increased pathology observed during RSV infection. This work was supported in part by NIH RO1AI036302.
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