Abstract
Carcinogen-produced squamous cell tumors in hamster oral mucosa were treated with dihematoporphyrin ether and red light. Oral mucosa in hamsters without tumors underwent a similar treatment. Tumors were eradicated with a drug dose of 3 mg/kg and light doses of 60–120 Joules/cm2. Normal oral mucosa was uneffected at these drug and light levels but damage did occur at 250–350 J/cm2. The time dependence and differential responses to PDT parallel data on the time-course and intensity of DHE fluorescence in the hamster animal model.Carcinogen-produced squamous cell tumors in hamster oral mucosa were treated with dihematoporphyrin ether and red light. Oral mucosa in hamsters without tumors underwent a similar treatment. Tumors were eradicated with a drug dose of 3 mg/kg and light doses of 60–120 Joules/cm2. Normal oral mucosa was uneffected at these drug and light levels but damage did occur at 250–350 J/cm2. The time dependence and differential responses to PDT parallel data on the time-course and intensity of DHE fluorescence in the hamster animal model.
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