Abstract
Breast cancer is the most common cancer among women worldwide. The survival rate of breast cancer is higher in first-world countries than in developing countries, which still rely on ethnomedicine. The seed oils of Kigelia africana, Mimusops zeyheri and Ximenia caffra previously demonstrated anti-proliferative effects on Caco-2 and HEK-293 cells in vitro. We determined the effects of these seed oils on hormone-dependent (MCF-7) and hormone-independent (MDA-MB-231) breast cancer cells. Different seed oil concentrations and different incubation times were evaluated. While the seed oils concentrations had no significant cytotoxicity or effect on MDA-MB-231 and MCF-7 viability; oil type and incubation time showed significant effects. Kigelia africana and X. caffra seed oils induced the greatest cytotoxic effects on hormone-independent MDA-MB-231 breast cancer cells, while X. caffra and M. zeyheri seed oils induced a growth inhibitory effect on hormone-dependent MCF-7 breast cancer cells. These effects are dependent on oil type/composition, duration of exposure and cell phenotype.
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