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Abstract
The ability of isoproterenol to relax guinea-pig trachea was examined in tissues precontracted with three concentrations of methacholine or three corresponding equieffective concentrations of leukotriene D 4. Although increasing the concentration of either contractile agent progressively shifted isoproterenol concentration-response curves to the right, the shifts produced by methacholine were greater than those produced by leukotriene D 4. Thus, the sensitivity of tracheal smooth muscle to β-agonists depends upon the initial contractile state of the tissue, and the type of agent used to induce tone.
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