Abstract
The basal and carrageenin-stimulated release of thromboxane (Tx) B 2, the stable product of TxA 2, 6-ketoPGF 1α, the stable breakdown product of prostacyclin (PGI 2) and prostaglandin (PG) E 2 from 24 h starch elicited rat peritoneal macrophages was inhibited by dibutyryl-cyclic AMP (db-cAMP). PGE 2 also inhibited the release of TxA 2 and 6-keto-PGF 1α whereas the stable endoperoxide analogue, U-44069, stimulated PGE 2 and 6-keto PGF 1α release but inhibited TxB 2 release. The effects of all three mediators tested were related to an increase of Mø intracellular cAMP content.
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