Abstract
To compare the effects of dexamethasone (Dex) and celecoxib (Cel) on F-isoprostane, prostacyclin (PGI 2), and thromboxane A 2 (TxA 2) following hyperoxia, and hyperoxia followed by recovery in room air (RA), newborn rabbits were exposed to hyperoxia (80–100% oxygen) for 4 days, during which they were treated with saline (Sal, i.m.), Dex (i.m.), vehicle (Veh, PO), or Cel (PO, n=12 per group). Six animals in each group were sacrificed immediately following hyperoxia, and the remainder allowed to recover in RA for 5 days. The control litters were treated simultaneously in RA with all conditions other than atmospheric oxygen being identical. Blood samples were assayed for 8-epi-prostaglandin F 2α (8-epi-PGF 2α), 6-keto prostaglandin F 1α (6-ketoPGF 1α), and TxB 2. Dex and Cel decreased 8-epi-PGF 2α during hyperoxia and the recovery period. Dex increased 6-ketoPGF 1α following hyperoxia, while similar increments were noted during recovery with Cel. Although TxB 2 was decreased only during the recovery period, TxB 2/6-ketoPGF 1α ratio was lower during hyperoxia and recovery in both treated groups. The effect of Cel on 8-epi-PGF 2α and TxA 2/PGI 2 ratio confirm the formation of a COX-derived F 2-isoprostane that is possibly linked to TxA 2 receptors. Further studies are required to examine whether Cel can be used as a therapeutic alternative to Dex for oxygen-induced injury in the newborn.
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