Abstract
Background Preimplantation mammalian embryo development is characterized by fundamental changes in nuclear function as genomes of gametes, egg and sperm unite to give rise to a totipotent embryonic genome. This totipotency is however a transient property since the first events of differentiation occur after few cell cycles, giving rise to the trophectoderm cells that co-exist with the pluripotent and no more totipotent cells of the inner cell mass at the blastocyst stage. Concomitantly to these cellular events, the newly formed embryonic genome becomes progressively transcriptionally active. We analyzed embryonic gene expression over this period in both the rabbit [1] and the bovine species. We have chosen these species as embryonic models in preference to the mouse since contrarily to this later species, embryonic genome activation (EGA) spans over several cell cycles and is preceded by progressive epigenetic modifications.
Highlights
Preimplantation mammalian embryo development is characterized by fundamental changes in nuclear function as genomes of gametes, egg and sperm unite to give rise to a totipotent embryonic genome
Frontiers of Retrovirology: Complex retroviruses, retroelements and their hosts Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1742-4690-6-S2-info.pdf
This totipotency is a transient property since the first events of differentiation occur after few cell cycles, giving rise to the trophectoderm cells that co-exist with the pluripotent and no more totipotent cells of the inner cell mass at the blastocyst stage
Summary
Véronique Duranthon*1, Alexei Evsikov, Daulat Khan, Linh Chi Bui, Roger Leandri, Adriana Rodrigues, Catherine Archilla, Alice Jouneau and. Address: 1INRA, UMR 1198 Biologie du Développement et Reproduction, F-78352 Jouy en Josas, France and 2The Jackson Laboratory, Bar Harbor, ME, USA. Published: 24 September 2009 Retrovirology 2009, 6(Suppl 2):P34 doi:10.1186/1742-4690-6-S2-P34. Frontiers of Retrovirology: Complex retroviruses, retroelements and their hosts Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1742-4690-6-S2-info.pdf
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