Year-end Sale % OFF 
Abstract
Slow delayed rectifier potassium current (IKs) conducted by KCNQ1 (pore-forming) and KCNE1 (auxiliary) ion channel complex is necessary to reset and recharge ventricular action potential. During exercise and flight-or-fight, IKs is upregulated via phosphorylation of KCNQ1 by Protein Kinase A (PKA) to maintain heart rhythm. The PKA holoenzyme (comprised of two regulatory RII and two catalytic Cα subunits) is recruited to the channel complex by A Kinase Anchoring protein (AKAP9), which binds to KCNQ1 C-terminus.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
