Abstract
Slow delayed rectifier potassium current (IKs) conducted by KCNQ1 (pore-forming) and KCNE1 (auxiliary) ion channel complex is necessary to reset and recharge ventricular action potential. During exercise and flight-or-fight, IKs is upregulated via phosphorylation of KCNQ1 by Protein Kinase A (PKA) to maintain heart rhythm. The PKA holoenzyme (comprised of two regulatory RII and two catalytic Cα subunits) is recruited to the channel complex by A Kinase Anchoring protein (AKAP9), which binds to KCNQ1 C-terminus.
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