Abstract
Opioid abuse can cause brain alterations, including neuroinflammation and increased risk for ischemic stroke. Cancer studies show that opioids affect angiogenesis and endothelial cell proliferation. However, human brain studies are scarce, and the molecular mechanisms of opioid-induced neurotoxicity are unclear. This study comprehensively interrogated the transcriptomic and proteomic profiles of the dorsolateral prefrontal cortex (BA9) in subjects with opioid use disorder (OUD), to investigate the molecular effects of opioid abuse in the human brain.
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