Differential pulse voltammetry study of gadolinium-DTPA complex

Abstract

The rare earth element (REE) is a group of elements with extensive use. One of the most used REEs is gadolinium (Gd) that is widely used as contrast agent. Gd complexes commonly used as contrasting compounds are Gd-DTPA. Gd-DTPA has been widely used in the health sector to diagnose various diseases because it is safe for the body and only gives mild side effects such as headaches, nausea and burning in the injection area. Gd-DTPA determination generally uses sophisticated but expensive methods such as Inductively Coupled Plasma (ICP) and Resonance Ionization Mass Spectrometry (RIMS). Therefore, other methods which are more affordable but have high sensitivity are needed. The voltammetry method has advantages such as providing simple footage, fast analysis time and low detection limit. The purpose of this study was to determine the current response of Gd-DTPA using differential pulse voltammetry (DPV) and voltammetry performance on Gd-DTPA analysis. In this study, an analysis of Gd-DTPA was carried out without and with reflux. The results obtained showed that preparation of Gd-DTPA without reflux did not form Gd-DTPA complexes whereas Gd-DTPA resulting from reflux formed Gd-DTPA complex compounds which produced a peak current at potential -1,4034 V with precision and accuracy for Gd-DTPA 15 mgL-1 as 98.83% and 99.00% respectively. Recovery was 101% with detection limit and quantization limit was 3.97 mgL-1 and 10.71 mgL-1 respectively.