Abstract
The electrochemical oxidation of bromocriptine at glassy carbon electrode has been carried out in Britton–Robinson (B–R) buffer solutions in the pH range 2.0–11.0 employing cyclic, linear sweep and differential pulse voltammetry (DPV). Bromocriptine showed one well-defined oxidation peak accompanied by a smaller one. The oxidation process was found irreversible. For analytical purposes, the well-resolved diffusion controlled voltammetric peak at pH 5 was critically investigated. The linear relationship between peak current height and bromocriptine concentration allowed the differential pulse voltammetric determination of the drug over a wide concentration range, from 0.04 to 5.00 μg ml −1 with a detection limit of 0.01 μg ml −1. A relative standard deviation of 1.44% at 0.1 μg ml −1 level was obtained. The proposed DPV method was successfully applied for the individual tablet assay to verify the uniformity content of bromocriptine in commercial tablets.
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