Abstract
An electrochemical sensor for the sensitive detection of acyclovir was developed by the electropolymerization of Eriochrome black T at a pretreated glassy carbon electrode. The surface morphology of the modified electrode was characterized by field emission scanning electron microscopy. Under the optimized conditions, a significant electrochemical improvement was observed toward the electrooxidation of acyclovir on the modified electrode surface relative to the unmodified electrode. The detection limit of 12nM and two linear calibration ranges of 0.03–0.3μM and 0.3–1.5μM were obtained for acyclovir determination using a differential pulse voltammetric method in acetate buffer (0.1M, pH4.0). Real sample studies were carried out in human blood serum and pharmaceutical formulations, which offered good recovery (98–102%). The electrode showed excellent reproducibility, selectivity and antifouling effects.
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