Abstract
Abstract A differential pulse polarographic (DPP) method is described for the detection and determination of JV-nitrosodiethanolamine (NDELA) in cosmetic products. The cosmetic sample is partitioned between IN HC1 and chloroform. The aqueous extract is isolated and further purified by passing it through a cartridge containing reverse phase high pressure liquid chromatographic (HPLC) packing (C18 Sep- Pak). Samples containing proteins are cleaned up by gel permeation chromatography. Direct polarographic interferences are removed by preparative HPLC. The prepared samples are then analyzed by polarography using the method of standard additions for quantitation. The DPP method can be used to determine NDELA in cosmetic products at levels as low as 100 ppb. Analyses of a commercial lotion and a commercial cream spiked at 3 levels in the ppm range gave recoveries ranging from 73 to 91%. The average of all recoveries was 80%.
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