Abstract

Objective: Candidate genes associated with preeclampsia have not been fully described. We conducted a microarray study to investigate global placental gene expression in preeclampsia.Study design: Cases (n=18) and controls (n=18) were selected among patients receiving care at Swedish Medical Center, Seattle, WA. Oligonucleotide probes representing 22,000 genes were used to measure gene expression. Differentially expressed genes were selected using criteria based on Students T‐test, fold change and Significance Analysis of Microarrays (SAM) analysis. Functions and functional relationships of differentially expressed genes were evaluated using Database for Annotation, Visualization and Integrated Discovery (DAVID) and Ingenuity Pathway Analysis (IPA) tools.Results: Genes (n=58) participating in immune system, inflammation, oxidative stress, signaling, growth and development pathways were differentially expressed in preeclampsia. These genes include previously described candidate genes (such as leptin, LEP), potential candidate genes with related functions (such as cytochrome P450 family 11 subfamily A, CYP11A) and novel genes (such as cyclin‐dependent kinase inhibitor 1C, CDKN1C).Conclusion: Expression of genes (both candidate and novel) with diverse functions is associated with preeclampsia risk, reflecting the complex pathogenesis.

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