Abstract
Lamins constitute the nuclear lamina, which underlie the inner membrane of the cell nucleus. Phosphorylation of lamins is a key factor in the regulation of nuclear structure during the cell cycle and of gene transcription. Since an uncontrolled cell cycle and altered gene transcription are major characteristics of neoplasms, we looked for differences in lamin B 2 phosphorylation between PBMC, ALL and AML cells. Using different lamin B 2-specific antibodies, we detected two different lamin B 2 species termed lamin B 2 and B 2A. Although phosphorylation of lamin B 2 in leukemic cells was reminiscent of resting cells, the majority of ALL and AML samples showed significantly higher and more altered lamin B 2A phosphorylation compared to PBMC. It remains to be elucidated which mechanism leads to these alterations and whether it could explain the extended G 1-phase frequently observed in ALL cells.
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