Abstract
Molecular genetic studies have uncovered a set of genes carrying somatic mutations in human brain tumors. While some molecular lesions are limited to distinct histopathological tumor types and grades, others exhibit a widespread distribution. This overlap and the limited number of identified genes currently restrict the feasibility of examining molecular lesions for diagnostic purposes. However, recent studies indicate that histopathological entities can be divided into molecular subsets based on characteristic and sometimes mutually exclusive genetic alterations. Among gliomas such genetic subsets have been described for glioblastomas and oligoastrocytomas. These observations should encourage researchers to include the examination of molecular parameters in study protocols for clinical and histopathological investigations.
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