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Abstract
Effects of intraocular injection of lead acetate, cadmium chloride, or mercury chloride on the sympathetic adrenergic ground plexus of the iris were studied using monoamine fluorescence histochemistry. Injection of 5 μl of a 1.4 m m lead solution into the anterior eye chamber caused a significant hyperinnervation as compared to sodium acetate-injected control irides. This hyperinnervation persisted 2 weeks after injection. Increasing the dose to 42 m m did not increase the extent of the hyperinnervation. Cadmium chloride solutions (1.4 and 7 m m) did not affect the adrenergic nerve fiber density as compared to sodium chloride-injected controls. Injection of mercury chloride caused a marked and dose-dependent degeneration of adrenergic nerves. Two weeks after injection of a 3.5 m m mercury chloride solution, the nerves had regenerated almost completely. Our results demonstrate that intraocular injections of neurotoxic heavy metals, and subsequent analysis with Falck-Hillarp fluorescence microscopy, is a rapid and sensitive method to evaluate adrenergic neurotoxicity.
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