Differential modulation of oscillatory activity in the human nucleus accumbens by face perception, target detection and novelty signaling

Abstract

Event Abstract Back to Event Differential modulation of oscillatory activity in the human nucleus accumbens by face perception, target detection and novelty signaling Till R. Schneider1*, Christian K. Moll1, Alessandro Gulberti1, Kathrin Müsch11, Bartosz Zurowski2, Dirk Rasche2, Andreas Kordon2, Jan Gliemroth2, Volker M. Tronnier2 and Andreas K. Engel1 1 University Medical Center Hamburg-Eppendorf, Germany 2 University Hospital Schleswig-Holstein, Campus Lübeck, Germany The nucleus accumbens is part of the ventral striatum and numerous studies have reported increased activity in response to rewarding and aversive stimuli. In addition, the nucleus accumbens is thought to operate as a filter for task-relevant information and thus may serve target detection. We tested the involvement of the nucleus accumbens in visual face processing (Experiment 1) and in auditory target detection using a novelty-oddball task (Experiment 2). To this end, we recorded local field potentials from deep brain stimulation electrodes implanted bilaterally in the ventral striatum of a patient suffering from severe obsessive compulsive disorder. In Experiment 1 faces and scrambled versions of the same faces were presented in a visual detection task. During face perception, oscillatory activity in the gamma frequency range (30-90 Hz) was selectively enhanced in the nucleus accumbens. In the novelty-oddball task (Experiment 2) frequent tones (p = 0.8) were interspersed with task-irrelevant unique ‘novel’ sounds (p = 0.1) and task-relevant target tones (p = 0.1). Oscillatory activity in the alpha (8-12 Hz) and the beta range (15-35 Hz) was enhanced in response to target compared to frequent stimuli. ‘Novel’ sounds elicited stronger activity in the alpha-range when compared to frequent stimuli, whereas target stimuli elicited enhanced beta-range activity compared to ‘novel’ sounds. Taken together, our data suggest that the distinct modulation of ventral striatal oscillatory activity plays a critical role in coding different aspects of saliency. Specifically, while beta band activity may signal top-down target detection, an increase of alpha band activity may reflect attentional gating (the bottom-up component of saliency processing) in the nucleus accumbens. Keywords: Intra-cranial Electrophysiology, Oscillatory activity Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Abstracts Citation: Schneider TR, Moll CK, Gulberti A, Müsch1 K, Zurowski B, Rasche D, Kordon A, Gliemroth J, Tronnier VM and Engel AK (2011). Differential modulation of oscillatory activity in the human nucleus accumbens by face perception, target detection and novelty signaling. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00062 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Nov 2011; Published Online: 25 Nov 2011. * Correspondence: Dr. Till R Schneider, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, t.schneider@uke.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Till R Schneider Christian K Moll Alessandro Gulberti Kathrin Müsch1 Bartosz Zurowski Dirk Rasche Andreas Kordon Jan Gliemroth Volker M Tronnier Andreas K Engel Google Till R Schneider Christian K Moll Alessandro Gulberti Kathrin Müsch1 Bartosz Zurowski Dirk Rasche Andreas Kordon Jan Gliemroth Volker M Tronnier Andreas K Engel Google Scholar Till R Schneider Christian K Moll Alessandro Gulberti Kathrin Müsch1 Bartosz Zurowski Dirk Rasche Andreas Kordon Jan Gliemroth Volker M Tronnier Andreas K Engel PubMed Till R Schneider Christian K Moll Alessandro Gulberti Kathrin Müsch1 Bartosz Zurowski Dirk Rasche Andreas Kordon Jan Gliemroth Volker M Tronnier Andreas K Engel Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.