Abstract
In 3 experiments gonadectomized male and female rats were administered tritiated progesterone. Brain tissues were analyzed for the retention of radioactivity using liquid scintillation techniques. Experiment 1. Estrogen-primed rats were sacrificed 30 min or 60 min after progesterone treatment. There was an increasing gradient of radioactivity from anterior hypothalamus through posterior hypothalamus to the region of the cerebral peduncle in the mesencephalon. Radioactivity levels were higher in females than in males only in anterior hypothalamus and plasma. Experiment 2. Estrogen-primed and non-estrogen-primed rats were sacrified 60 min after progesterone treatment. Estrogen priming had no influence on the retention of radioactivity. The mesencephalic sample retained more radioactivity than the diencephalic tissues. Tissues from females retained more radioactivity than tissues from males. Experiment 3. Adrenalectomized and sham-operated animals were sacrificed 60 min after progesterone treatment. Adrenalectomized animals retained from 27.6 to 51.3% more radioactivity than control animals. Mesencephalic tissues retained more radioactivity than diencephalic tissues. The results suggest the existence of limited capacity binding sites for progesterone in the mesencephalon and diencephalon as well as the pituitary.
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