Abstract
The functions of the 5-hydroxytryptamine 3 (S-HT 3) and 5-hydroxytryptamine 4 (5-HT 4) receptors in gastrointestinal tract are complex depending on the species and anatomical regions, and the localization of these receptors in the human rectum was unclear. We examined the localization of the 5-HT 3 and 5-HT 4 receptors in human rectum by in vitro receptor autoradiography using [ 125I](S)iodozacopride and [ 125I] SB207710 as a ligand, respectively. Specific [ 125I](S)iodozacopride binding sites were clearly evident in the myenteric plexus, whereas, low levels of [ 125I]SB207710 binding sites were distributed over the muscle but not to the myenteric plexus. The 5-HT 3 receptor located on the myenteric plexus and the 5-HT 4 receptor on the smooth muscle may participate in contractility and relaxation of human rectum, respectively.
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