Differential ligand-signaling network of CCL19/CCL21-CCR7 system.

Rajesh Raju,T S K Prasad,Jayshree Advani,Priyanka Gopal,Sowmya Soman,Reshmi Girijadevi,Bijesh George,Sachin Gadakh

doi:10.1093/database/bav106

Rajesh Raju, T S K Prasad + Show 6 more

Open Access

https://doi.org/10.1093/database/bav106

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Abstract

Chemokine (C-C motif) receptor 7 (CCR7), a class A subtype G-Protein Coupled Receptor (GPCR), is involved in the migration, activation and survival of multiple cell types including dendritic cells, T cells, eosinophils, B cells, endothelial cells and different cancer cells. Together, CCR7 signaling system has been implicated in diverse biological processes such as lymph node homeostasis, T cell activation, immune tolerance, inflammatory response and cancer metastasis. CCL19 and CCL21, the two well-characterized CCR7 ligands, have been established to be differential in their signaling through CCR7 in multiple cell types. Although the differential ligand signaling through single receptor have been suggested for many receptors including GPCRs, there exists no resource or platform to analyse them globally. Here, first of its kind, we present the cell-type-specific differential signaling network of CCL19/CCL21-CCR7 system for effective visualization and differential analysis of chemokine/GPCR signaling.Database URL: http:// www. netpath. org/ pathways? path_ id= NetPath_ 46.

Highlights

CCL19 and CCL21, known as EBI1-Ligand Chemokine/Macrophage Inflammatory Protein-3b (ELC/ MIP-3b) and Secondary Lymphoid-tissue Chemokine (SLC), respectively, are the major chemokines predominantly expressed in secondary lymphoid tissues [1,2,3]
Elevated expression of the chemokines CCL19 and CCL21 have been reported in diverse disease conditions such as atherosclerosis [4, 5], cancers, bone disorders [6, 7] and other inflammatory conditions such as asthma [8], HIV infection [9] and pneumonia [10]
CCL21 differ from CCL19 in that it has an extra 32 amino acid C-terminus of basic amino acids that may mediate the distinct binding of CCL21 to other molecules [11, 12]

Summary

Introduction

CCL19 and CCL21, known as EBI1-Ligand Chemokine/Macrophage Inflammatory Protein-3b (ELC/ MIP-3b) and Secondary Lymphoid-tissue Chemokine (SLC), respectively, are the major chemokines predominantly expressed in secondary lymphoid tissues [1,2,3]. CCR7 signaling pathway reactions CCL19 CCL21 Cell lines/types To analyse the differential signaling of CCR7 ligands further, the experimentally proven molecular reactions induced by CCR7 ligands should be made available in computationally analysable formats such as BioPAX, SBML or GPML formats in a cell-type-specific manner [25,26,27].

Results

Conclusion