Differential insulin signaling regulation in skeletal muscle and adipose tissue from old rats fed a long-term leucine excess

Abstract

Leucine acts as a signal nutrient in promoting protein synthesis in skeletal muscle and adipose tissue via mTOR/S6K1 pathway activation, and may be of interest to prevent age-related sarcopenia. However, hyper-activation of mTOR/S6K1 has been suggested to inhibit the first steps of insulin signaling and finally promote insulin resistance.