Abstract
The influence of progesterone on contractile activity of three gastrointestinal regional tissues was evaluated. Up to six dose levels of progesterone were administered subcutaneously to male rats daily for four days. Progesterone blood levels measured with radioimmunoassay on the fourth day revealed that the range of progesterone exposure to the male animals did not exceed the progesterone blood level peak reported during the normal hormonal cycle of female rats. Log-dose response curves indicate that esophageal, antral, and colonic tissues from progesterone treated animals showed a significant reduction in contractile activity compared to the corresponding tissue from non-progesterone treated control animals. Esophageal and colonic tissues were two and 12-fold, respectively, more sensitive to the inhibitory progesterone influence compared to antral tissue. This study supports the concept that normal circulating levels of progesterone may have an influence on specific gastrointestinal regional function in addition to the effects of progesterone blood levels during pregnancy.
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