Abstract
IntroductionSyphilis rapid test results may be influenced by numerous environmental and genetic factors.MethodsThe proportion of false positive syphilis non-treponemal (NT) and treponemal (T) test results using immuno-chromatographic dual syphilis rapid test on serum from Cameroonian blacks (n=103) versus French blacks (n=104) or French caucasians (n=51), all HIV-negative and free of clinical syphilis, was examined.ResultsBlack individuals in Cameroon had a significantly higher frequency of false positive NT or T tests than black individuals in France. black individuals in France had a higher frequency of indeterminate NT tests as compared to caucasians in France.ConclusionBoth racial and environmental factors may affect immuno-chromatographic dual syphilis rapid testing.
Highlights
Syphilis rapid test results may be influenced by numerous environmental and genetic factors [1,2,3,4,5,6]
Treponemal T reactivities by syphilis rapid test on sera from individuals from Central Africa (9.7%) were more frequent than that observed on sera from black and caucasian individuals living in France (1.9% and 0.0%, respectively) (P
Black individuals living in France were more frequently indeterminate by dual syphilis rapid test than caucasian individuals living in France
Summary
Syphilis rapid test results may be influenced by numerous environmental and genetic factors [1,2,3,4,5,6]. We report on the frequency of false-positive non-treponemal (NT) and treponemal (T) tests using a dual syphilis rapid test on serum from black individuals living in Central Africa versus black and caucasian individuals living in France
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