Abstract
The main goal of this study was to establish how the inflammation caused by infection with two different Salmonella enterica serotypes, S. Typhimurium and S. Enteritidis, may lead to the predisposition to allergy as measured by total IgE level in the blood. Infection by S. Typhimurium did not affect the systemic IgE concentration while in S. Enteritidis-infected patients there was a significant 3.5-fold increase. This effect was especially profound in patients >4 years old, with up to the 8-fold increase above the norm. The degree of dysbiosis in these two infections measured with the comparative counts of cultivated bacteria showed an inverse relationship with the IgE concentration. Earlier we reported the elevated level of IL-17 in patients infected by S. Enteritidis. In the current study a significant correlation was found between the concentrations of IL-17 and IgE suggesting a possible role played by this cytokine in triggering the production of IgE in response to S. Enteritidis infection.
Highlights
IntroductionIn many countries the most frequent intestinal infection is salmonellosis, which is caused by various serotypes of non-typhoidal Salmonella (Rabsch et al, 2001)
Intestinal infectious diseases remain a serious problem for the health care systems
Enteritidis Infections We found a significant 3.5-fold increase of systemic IgE in patients of both age groups infected by S
Summary
In many countries the most frequent intestinal infection is salmonellosis, which is caused by various serotypes of non-typhoidal Salmonella (Rabsch et al, 2001). Except for norovirus infections, Salmonella is a single most common causative agent among food-borne diseases (Centers for Disease Control and Prevention, 2013). Gastroenteritis is most frequently caused by Salmonella enterica serovar Typhimurium Enteritidis), which are prevalent in Armenia (Ktsoyan et al, 2013). The former serovar has been predominantly reported before the 1980’s but beginning from the 1990’s the latter becomes the predominant serovar isolated from the salmonellosis cases (Angulo and Swerdlow, 1999; Munro et al, 1999; Tschape et al, 1999)
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