Abstract
The influence of PGF2∝ on c- jun gene expression in ovary, uterus and adrenal was examined. Three and seven day postovulatory PMSG primed immature rats received 500 μg PGF2∝ by two subcutaneous injections 8 hours apart. Control rats received saline. Animals were sacrified 30 minutes after the second injection of PGF2∝. Tissues were obtained and frozen in liquid nitrogen. RNA extracted from ovary, uterus and adrenal was analyzed by Northern and slot blot. c- jun was expressed differentially in these organs. An increase in c- jun expression by PGF2∝ treatment occurred in the ovary but not in the adrenal and uterus. The effect of PGF2∝ on c- jun was stronger in older compared to younger corpora lutea. These results indicate differential regulation of c- jun by PGF2∝ in steroidogenic and steroid responsive tissues and that c- jun might be linked to the mode of action of PGF2∝ in luteolysis.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
