Abstract
The changes in cytoplasmic pH (pHi) accompanying the morphological transition of Candida albicans were studied using a nongerminative variant. A transient cytoplasmic alkalinization at the time of evagination was observed in both the variant and its parent. Under zinc-deficient conditions the wild-type cells that formed buds at pH 4.5 and mycelia at pH 6.5 showed an increase in pHi of 0.58 and 0.12 pH units, respectively. Under similar conditions the pHi of the nongerminative variant that formed buds at both pH 4.5 and 6.5 increased by 0.66 and 0.40 pH units, respectively, suggesting that a greater magnitude of increase in pHi at the time of evagination is probably needed for bud formation. These results provide evidence for a correlation between intracellular alkalinization and time of cell differentiation in C. albicans.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
