Differential impairments of rat serial pattern learning and retention induced by MK-801, an NMDA receptor antagonist

Abstract

Three experiments investigated the role of NMDA receptor dependent systems in sequential learning and memory. Rats tracked serial patterns after systemic administration of MK-801, an NMDA receptor antagonist that blocks plasticity in the hippocampus and other structures. Experiments 1 and 2 sought to describe the effects of MK-801 on acquisition and retention of serial patterns. Patterns were 24 elements long and highly organized, with some groups receiving a “violation” element that did not fit the organization of the rest of the pattern. Experiment 3 evaluated MK-801’s effects on the integration of new information that was either consistent or inconsistent with a previously learned pattern structure. The results of these experiments indicated that MK-801 interfered with serial pattern learning and, to a lesser degree, retention. Learning about structure was relatively spared, whereas learning about interruptions or violations of pattern structure was impaired. The latter differential effects are consistent with the contention in earlier literature that serial pattern learning is subserved by at least two learning/memory systems.