Abstract
The function of the γ-aminobutyric acid B (GABA B) receptor, measured as baclofen-stimulated [ 35S]GTPγS binding, was evaluated in some brain regions of Sardinian alcohol-preferring (sP) and -nonpreferring (sNP) rats. EC 50 value of baclofen-stimulated [ 35S]GTPγS in limbic areas was approximately 125% higher in alcohol-naive sP than sNP rats; voluntarily consumed alcohol reduced the EC 50 value to a level similar to that of alcohol-naive sNP rats. These results suggest the presence of a genetically determined lower function of the GABA B receptor in limbic areas of sP than sNP rats; this differential functioning of the GABA B receptor may contribute to the opposite preference for alcohol in these rat lines.
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