Differential expression of seven mitochondrion enzymes in osteoarthritis cartilages and normal cartilages

Abstract

Osteoarthritis (OA) is an aging-associated rheumatic disease characterized by reduced number of chondrocytes, loss of existing cartilage extracellular matrix, the production of matrix with abnormal composition and pathologic matrix calcification. Recent studies have reported mitochondrial dysfunction played an important role in human OA chondrocytes. Although several lines of evidence support the role for declines in enzyme activity in the etiology of OA, it remains unclear if the expressions of enzymes alter with OA. Here, we determined to quantify the expression of several enzymes in ETC and cytoplasm of mitochondrial in healthy and OA cartilage. These findings suggest that the decreased expression of enzymes in mitochondrial may contribute to OA.