Differential expression of protein kinase C - α and - βII in rat septum and changes following fimbria–fornix lesion

Abstract

Protein kinase C (PKC)- α and - βII are expressed specifically and differentially in the septal formation. Following unilateral fimbria–fornix lesions, there was a marked reduction in punctiform PKC- α immunoreactivity in the lateral septum and in the number of PKC- βII immunoreactive neurons in the medial septum and the lateral septum, while some PKC- α and PKC- βII immunoreactive glia-like cells were observed in the lateral septum. The response of each PKC isozyme to this lesion supports the suggested role for PKC in the plasticity of the central nervous system.