Abstract
This study aimed to investigate the spatial distribution and clinical significance of podoplanin expression in the metastatic lymph nodes of oropharyngeal squamous cell carcinomas (OPSCCs). The immunohistochemical podoplanin expression in the metastatic lymph nodes was evaluated in the pathologic specimens of 47 consecutive OPSCC patients. Clinicopathologic factors, including podoplanin expression and extranodal extension (ENE) status, were analyzed. Podoplanin was significantly expressed in the perinodal stroma (p = 0.001), and the average score of podoplanin was higher (p = 0.008) in ENE-positive lymph nodes than ENE-negative lymph nodes, although intranodal podoplanin expression did not differ significantly between the groups. Multivariable analysis revealed perinodal podoplanin expression as an independent marker of ENE in all the patients and the human papilloma virus (HPV)-positive group (p = 0.007 and p = 0.018, respectively). Podoplanin is differentially expressed in the metastatic lymph nodes in OPSCC, and its expression in perinodal stroma is associated with ENE, suggesting that podoplanin can be used clinically as a diagnostic biomarker.
Highlights
This study aimed to investigate the spatial distribution and clinical significance of podoplanin expression in the metastatic lymph nodes of oropharyngeal squamous cell carcinomas (OPSCCs)
Oropharyngeal squamous cell carcinoma (OPSCC), which consists of a subgroup of head and neck cancers (HNCs), includes squamous cell cancers arising from the tonsils, base of the tongue, posterior pharyngeal wall, and soft p alate[1,2]
This study aimed to comprehensively explore the expression of podoplanin in all areas of metastatic cervical lymph nodes of OPSCC patients, including intranodal metastatic tumor sites and the perinodal stroma corresponding to the tumor stroma of extranodal extension (ENE) invasive front, through immunohistochemical staining and pathological evaluation
Summary
This study aimed to investigate the spatial distribution and clinical significance of podoplanin expression in the metastatic lymph nodes of oropharyngeal squamous cell carcinomas (OPSCCs). The immunohistochemical podoplanin expression in the metastatic lymph nodes was evaluated in the pathologic specimens of 47 consecutive OPSCC patients. Podoplanin is differentially expressed in the metastatic lymph nodes in OPSCC, and its expression in perinodal stroma is associated with ENE, suggesting that podoplanin can be used clinically as a diagnostic biomarker. This study aimed to comprehensively explore the expression of podoplanin in all areas of metastatic cervical lymph nodes of OPSCC patients, including intranodal metastatic tumor sites and the perinodal stroma corresponding to the tumor stroma of ENE invasive front, through immunohistochemical staining and pathological evaluation
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