Abstract
On day 4 after sciatic nerve crush injury, expression and localization of endothelin receptors ET A and ET B in the lumbar spinal cord were examined. Immunohistochemical staining with antibodies to ET A and ET B receptors showed cytoplasmic distribution of ET A receptors in motor neurons, whereas ET B receptors were localized in the perinuclear region. On the injured side of the lumbar spinal cord, when compared to contralateral, results demonstrated an up-regulation of ET B and a down-regulation of ET A receptors expression at the level of both mRNA and protein. These results suggest that ET B receptors may play a role in the regeneration of axotomized motor neurons.
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