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Abstract
The acutely oncogenic retroviruses induce a wide spectrum of malignancies including sarcomas, carcinomas, lymphomas and leukaemias1. They all contain sequences which are required for neoplastic transformation as an integral part of their genomes1–3. These sequences, termed viral oncogenes (v-onc), apparently originated from the normal vertebrate genome.To date, cellular homologues of over a dozen different oncogenes of acutely oncogenic viruses have been identified1–4. Although transcription of some c-onc genes has been detected in normal vertebrate cells1,5–7, relatively little is known about their role in normal cell metabolism. We describe here stage- and tissue-specific expression of cellular genes homologous to the oncogenes of FBJ murine osteosarcoma virus, Abelson imirine leukaemia virus and Harvey sarcoma virus during mouse prenatal and early postnatal development. Our results suggest participation of cellular oncogenes in normal developmental processes.
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