Abstract
Dental implants are crucial therapeutic devices for successful substitution of missing teeth. Failure cases are mainly pathogen-associated events, allowing clinical progression toward peri-mucositis or peri-implantitis. The aim of this study was to compare the performance of two mechanical decontamination systems, Nickel-Titanium brush (Brush) and Air-Polishing system with 40 µm bicarbonate powder (BIC-40), by means of a novel bioluminescence-based model that measures microbial load in real time. Briefly, 30 disks were contaminated using the bioluminescent Pseudomonas aeruginosa strain (BLI-P. aeruginosa), treated with Brush (30 s rounds, for 90 s) or BIC-40 (30 s, at 5 mm distance) procedure, and then assessed for microbial load, particularly, biofilm removal and re-growth. Our results showed that Brush and BIC-40 treatment reduced microbial load of about 1 and more than 3 logs, respectively. Furthermore, microbial re-growth onto Brush-treated disks rapidly occurred, while BIC-40-treated disks were slowly recolonized, reaching levels of microbial load consistently below those observed with the controls. In conclusion, we provide evidence on the good performance of BIC-40 as titanium device-decontamination system, the clinical implication for such findings will be discussed.
Highlights
To achieve a successful oral rehabilitation, aimed at substituting one or more missing teeth via dental implants, such as titanium (Ti) element or titanium alloys [1], it is important to obtain implant osseointegration and to limit, as much as possible, the risk of peri-implant disease [2]
The titanium disks were firstly sterilized by autoclave
We show that BIC-40 system performs better than Brush in reducing P. aeruginosa biofilm and microbial re-growth onto titanium disks
Summary
To achieve a successful oral rehabilitation, aimed at substituting one or more missing teeth via dental implants, such as titanium (Ti) element or titanium alloys [1], it is important to obtain implant osseointegration and to limit, as much as possible, the risk of peri-implant disease [2]. Peri-implantitis is a chronic, irreversible, multifactorial condition, triggered by microbial biofilm formation, and persistent inflammation around dental implants [3,4,5], especially in patients with insufficiently poor oral hygiene, smoking, diabetes, history of periodontitis, trauma, or fracture due to uncontrolled implant-overload [6,7]. It has been hypothesized that some subjects are genetically predisposed to the onset and progression of peri-implantitis
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