Abstract
Following neonatal 6-hydroxydopamine treatment the noradrenaline content of the frontal cortex, the periventricular nucleus, the arcuate nucleus and the median eminence, but not that of the paraventricular nucleus, the supraoptic nucleus and the dorsomedial nucleus, was significantly decreased compared to that of vehicle treated controls 13 weeks after birth. The adrenaline concentration of the periventricular nucleus was slightly lowered. An elevated noradrenaline concentration was observed in the locus coeruleus, the A5 region and the nucleus reticularis medullae oblongatae pars ventralis. In the latter two regions the dopamine levels were increased as well. It is concluded (a) that not all hypothalamic terminal areas of locus coeruleus neurons are equally affected by 6-hydroxydopamine (6-OHDA) and (b) that also noradrenergic projections of brain stem cell body regions other than the locus coeruleus are affected.
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