Abstract
Through interacting with BDNF, vascular endothelial growth factor (VEGF) has been implicated in the antidepressant action of ketamine. VEGF is also linked to pigment epithelial-derived factor (PEDF), which inhibits VEGF and is neurotrophic. Plasma PEDF is increased in depressed patients and further increased post-ECT. We therefore explored the effect of single ketamine infusions on peripheral blood mRNA levels of VEGFA and PEDF (SERPINF1) and their relationship in patients with depression.
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