Abstract
The effects of interleukin-1β, interleukin-2 and interferon-γ and their combinations were investigated on induced cytochrome P 4501A of cultured rabbit hepatocytes considered 72 h after plating. Without apparent cellular toxicity, these cytokines provoke a significant decrease in TBZ- and BNF-induced P4501A1/2 expression. However specific patterns of action are revealed : IL-1β is the most potent cytokine in regard to CYP1A1/2 mRNA suppression whereas IL-2 exerts repressive effects only on P4501A1 induced expression. Although being a strong inhibitor of induced enzymatic activities and protein contents, IFN-γ exhibits only a weak influence on CYP1A1/2 mRNAs with the exception of its association with interleukins. All these results suggest that IL-1β and IL-2 promote mainly a transcriptional repression mechanism whereas IFN-γ would stimulate a post-transcriptional suppressive pathway.
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