Abstract
ω-Conotoxin GVIA and ω-conotoxin MVIIC caused similar concentration-dependent reductions of the electrically induced twitch responses of guinea-pig ileum. The inhibitory effects of ω-conotoxin GVIA were long-lasting whereas those to ω-conotoxin MVIIC were readily reversed. Preincubation with ω-conotoxin MVIIC prevented the irreversible inhibition of ω-conotoxin GVIA suggesting a common site of interaction. However, unlike ω-conotoxin GVIA which caused inhibition, ω-conotoxin MVIIC did not affect the electrically induced twitch responses of the rat vas deferens nor did it prevent the irreversible inhibition with ω-conotoxin GVIA. This study indicates the possible existence of different subtypes of the N-type voltage-dependent calcium channel.
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