Abstract
The effects of chronic clomipramine, imipramine and clorgyline on 5-HT 1C receptors were studied in discrete brain regions, in male Wistar rats, using [ 3H]mesulergine to label the receptor binding sites. Clorgyline treatment significantly reduced [ 3H]mesulergine binding (B max values) in both the hypothalamus and striatum compared to saline-treated animals. There were no differences in the maximum number of [ 3H]mesulergine binding sites following clorgyline in the hippocampus, frontal cortex or brainstem. Neither clomipramine or imipramine treatment resulted in any significant changes in 5-HT 1C receptor number in the brain regions examined here. Furthermore, the K d values (receptor affinity) for [ 3H]mesulergine binding were not significantly different comparing treatment groups to control animals. The significant changes in discrete brain regions following chlorgyline treatment suggest that 5-HT 1C receptors may be involved in the clinical efficacy for the treatment of depression and other neuropsychiatric disorders.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
