Abstract
The effects of chronic clomipramine, imipramine and clorgyline on 5-HT 1C receptors were studied in discrete brain regions, in male Wistar rats, using [ 3H]mesulergine to label the receptor binding sites. Clorgyline treatment significantly reduced [ 3H]mesulergine binding (B max values) in both the hypothalamus and striatum compared to saline-treated animals. There were no differences in the maximum number of [ 3H]mesulergine binding sites following clorgyline in the hippocampus, frontal cortex or brainstem. Neither clomipramine or imipramine treatment resulted in any significant changes in 5-HT 1C receptor number in the brain regions examined here. Furthermore, the K d values (receptor affinity) for [ 3H]mesulergine binding were not significantly different comparing treatment groups to control animals. The significant changes in discrete brain regions following chlorgyline treatment suggest that 5-HT 1C receptors may be involved in the clinical efficacy for the treatment of depression and other neuropsychiatric disorders.
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