Abstract
Forty-eight chronic schizophrenic subjects were randomly divided into chlorpromazine and reserpine treatment groups for a period of three months. After this phase, half of the subjects in each group were switched to the other drug. Pre-drug ratings by an abridged Lorr Multidimensional Rating Scale and various psychological tests, monthly ratings, and psychological testing every third month were carried out. No significant behavioral differences were found for the six-month period, although reserpine—at the end of the third month—tended to be temporarily superior in its action. Analysis of behavioral change disclosed that chlorpromazine produced significant effects after the first month, whereas a reserpine build-up until the third month was necessary before conclusive behavioral changes occurred. In general, no significant differences in psychological test performances were found between the various groups.
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