Abstract
Objectives: The amount of fat tissue is associated with an increasing incidence of cardiac arrhythmias. The purpose of this study was to investigate effects of adipocytokines from different body fat on delayed rectifier K<sup>+</sup> outward currents (I<sub>K</sub>). Methods: H9c2 cells were treated with adipocytokine-free medium (the Adipo-free group) and with adipocytokines from epicardial (central fat group) and limb (peripheral fat group) rat fat tissues. I<sub>K</sub>, as well as expressions of Kv2.1 and Kv2.1 mRNA in H9c2 cells, were measured and compared between different groups. Results: I<sub>K</sub> measured in H9c2 cells immediately after treatment with adipocytokines were not significantly different from those treated with adipocytokine-free medium. After H9c2 cells were treated with adipocytokines for 18 h, I<sub>K</sub> were significantly decreased in the peripheral and central fat groups in comparison with the Adipo-free group. Compared with the peripheral fat group, I<sub>K</sub> were more significantly decreased in the central fat group. Expressions of Kv2.1 and Kv2.1 mRNA in H9c2 cells were not significantly different among the three groups. Conclusions: Adipocytokines significantly decreased I<sub>K</sub> in H9c2 cells, and I<sub>K</sub> was more prominently decreased by adipocytokines from epicardial fat than from limb fat tissues. The decrease in I<sub>K</sub> by adipocytokines may partially contribute to the mechanisms of arrhythmogenesis by fat tissues.
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