Abstract
The effects of angiotensin II (All) on the firing rates of suprachissmatic neurons were determined in rat brain slices. All in pmol ranges stimulated 25% and inhibited another 25% of 52 irregular firing neurons, while it stimulated 23% and Inhibited 4% of 30 regular firing neurons. Three “oscillating” neurons whose firing rates oscillated with rather constant amplitudes and periods were recorded. All induced the occurrence of oscillation in one unit and modulated the oscillation amplitude of the other two. Pretreatment with saralasin, an All antagonist, effectively blocked (100%) the actions of All ( n = 5). The present findings suggest that All may act as an important mediator in the suprachissmatic nucleus and its mode of action may be variable in different neurons.
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