Abstract
Mouse embryo fibroblast cultures were exposed to various concentrations of amorphous or crystalline NiS (nickel sulfide). After removal of the NiS from the cultures, polyriboinosinic-polyribocytidylic acid was added to induce α β interferon. Pretreatment of the cultures with crystalline NiS significantly inhibited the production of α β interferon at relatively noncytotoxic concentrations (i.e., 1 μg/ml) while amorphous NiS had no significant effect on α β interferon production at 10 μg/ml. Treatment of cells with reduced glutathione did not block the inhibitory effects of crystalline NiS on α β interferon production, suggesting that these effects are not mediated by a free-radical mechanism.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
